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GLP-1 receptor agonists exert their therapeutic effects through several mechanisms : they stimulate insulin secretion from pancreatic beta cells in a glucose-dependent manner, suppress glucagon release (which reduces hepatic glucose production), slow gastric emptying, and act on appetite centres in the hypothalamus to promote satiety and reduce food intake

A study indicated that exenatide alleviates the reduction in local motor activity and anxiety-like behavior in mice caused by a HFD (Lin et al., 2023)

Last question is about side effects

Vomiting is rare in our patients because we start with microdosing and gently increase the dose

Connecting those anecdotal accounts with the fact that there are GLP-1 receptors in the brain in regions that modulate reward processing, and therefore might affect cravings, Al-Aly and his collaborators investigated whether GLP-1s could treat all substance use disorders